Odelia Schwartz

Automated model-based spike-sorting: a method for classification with confidence intervals

New York University

Spike-triggered average (reverse correlation) techniques are effective for linear characterization of neural responses. But sensory neurons exhibit important nonlinear behaviors that are not captured by such analyses. Many of these nonlinear behaviors are consistent with gain control. We assume a model in which the spike rate of a neuron is proportional to the halfwave rectified response of a linear kernel suppressively modulated by a weighted sum of rectified responses of other linear kernels. We develop a spike-triggered covariance method for recovering the suppressive axes of such a model. First, we recover a linear kernel through spike triggered averaging. Next, we compute the covariance matrix of the stimuli eliciting spikes, and perform a principal components decomposition of this matrix. The principal axes (eigenvectors) associated with small variance (eigenvalue) correspond to directions in which the response of the neuron is modulated suppressively. Finally, we recover the suppressive weights associated with these axes by maximizing the likelihood of the spike data. We demonstrate this method on simulated examples and on salamander retinal ganglion cell data (from the Chichilnisky lab). Preliminary analysis of the physiological data reveals meaningful suppressive axes and explains interesting nonlinearities. We believe this method will be applicable to other sensory areas and modalities.

Monday, June 5, 2023
About the Swartz Foundation...
The Swartz Foundation was established by Jerry Swartz (bio) in 1994 . . .
Follow us...
The Swartz Foundation is on Twitter: SwartzCompNeuro
2013 Stony Brook Mind/Brain Lecture - Michael Wigler, PhD
2012 Stony Brook Mind/Brain Lecture - John Donoghue
Sloan-Swartz Centers Annual Meeting 2011
2011 Stony Brook Mind/Brain Lecture - Allison J. Doupe
2011 Banbury Workshop
Sloan-Swartz Centers Annual Meeting 2010
2010 Stony Brook Mind/Brain Lecture
Sloan-Swartz Centers Annual Meeting 2009
Conference on Neural Dynamics
2009 Stony Brook Mind/Brain Lecture
Canonical Neural Computation, April 2009
2009 Banbury Workshop
Sloan-Swartz Centers Annual Meeting 2008
Theoretical and Experimental Approaches to Auditory and Visual Attention - Banbury 2008
Stony Brook Mind/Brain 2008: Patricia Smith Churchland, B. Phil. D
Sloan-Swartz Centers Annual Meeting 2007
New Frontiers In Studies Of Nonconscious Processing - Banbury 2007
Stony Brook Mind/Brain 2007: Professor Michael Shadlen, MD, PhD
Multi-level Brain Modeling Workshop 2006
Sloan Swartz Centers Annual Meeting 2006
Banbury 2006: Computational Approaches to Cortical Functions
Stony Brook Mind/Brain 2006: Helen Fisher -- Lecture Videos
Sloan-Swartz Centers for Theoretical Neurobiology
Swartz Center for Computational Neuroscience
Banbury Center Workshop Series
Other Events
www.theswartzfoundation.org                           Copyright © The Swartz Foundation 2023